Título:
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Indole Synthesis via Sequential Electrophilic N-H and C-H Bond Activation using Iodine(III) Reactivity
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Autor/a:
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Fra, Laura; Muñiz, Kilian
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Abstract:
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An intramolecular approach towards the regioselective construction of 2,3-diarylated indoles is reported. The reaction follows an intramolecular approach of an electrophilic N-H and C-H bond functionalization between an aniline and an acetylene. It employs the concept of a traceless tether to provide access to the free 2,2-diarylated indole products comprising a total of 18 examples. Hypervalent iodine reagents were identified as suitable promoters and four different protocols are provided including stoichiometric and catalytic transformations. |
Fecha de creación:
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2016 |
Materia(s):
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Catalysis Hypervalent Iodine Indoles Oxidation Tether |
Derechos:
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1999 - 2016 John Wiley & Sons, Inc. |
Tipo de documento:
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Artículo |
DOI:
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https://dx.doi.org/10.1002/chem.201504974
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Editor:
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WIley
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Publish at:
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Chemistry A. European Journal
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Compartir:
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