Title:
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An Improved Catalyst for Iodine(I/III)-Catalysed Intermolecular C-H Amination
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Author:
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Lucchetti, Nicola; Scalone, Michelangelo; Fantasia, Serena; Muñiz, Kilian
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Abstract:
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1,2-Diiodobenzene is presented as an efficient catalyst precursor for the intermolecular amination of arenes under homogeneous conditions. N-Troc and N-phthalimido-substituted methoxyamines serve as suitable nitrogen sources providing the corresponding aniline derivatives in up to 99% yield and with up to 66:1 regioselectivity. Key for this successful C-N coupling protocol is the strained m-oxo-bridged conformation of the bisiodine(III) catalyst, which induces unparalleled high reactivity. |
Publication date:
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2016 |
Subject(s):
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Amination Arenes C-H Functionalization Catalysis Hypervalent Iodine |
Rights:
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WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
Document type:
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Article |
DOI:
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https://dx.doi.org/10.1002/adsc.201600191
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Published by:
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WIley
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Publish at:
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Advanced Synthesis & Catalysis
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Share:
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