Título:
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Asymmetric Hydrogenation of Seven-membered C=N-containing Heterocycles and Rationalization of the Enantioselectivity
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Autor/a:
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Balakrishna, Bugga; Bauzá, Antonio; Frontera, Antonio; Vidal-Ferran, Anton
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Abstract:
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Iridium(I) complexes of phosphine-phosphite ligands efficiently catalyze the enantioselective hydrogenation of diverse seven-membered C=N-containing heterocyclic compounds (eleven examples; up to 97% ee). P-OP ligand L3, which incorporates an ortho-diphenyl substituted octahydrobinol phosphite fragment, provided the highest enantioselectivities in the hydrogenation of most of the heterocyclic compounds studied. The observed sense of stereoselection was rationalized by means of DFT calculations. |
Fecha de creación:
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2016 |
Materia(s):
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Enantiopure heterocycles Asymmetric hydrogenation Substrate activation Iridium Phosphine-phosphites |
Derechos:
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© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
Tipo de documento:
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Artículo |
DOI:
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https://dx.doi.org/10.1002/chem.201601464
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Editor:
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WILEY-VCH
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Publish at:
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Chemistry – A European Journal
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Compartir:
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