Title:
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Auditory target and novelty processing in patients with unilateral hippocampal sclerosis: A current-source density study
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Author:
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Vilà-Balló, Adrià; François, Clément; Cucurell, David; Miró, Júlia; Falip, Mercè; Juncadella i Puig, Montserrat; Rodríguez Fornells, Antoni
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Other authors:
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Universitat de Barcelona |
Abstract:
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The capacity to respond to novel events is crucial for adapting to the constantly changing environment. Here, we recorded 29-channel Event Related Brain Potentials (ERPs) during an active auditory novelty oddball paradigm and used for the first time Current Source Density-transformed Event Related Brain Potentials and associated time-frequency spectra to study target and novelty processing in a group of epileptic patients with unilateral damage of the hippocampus (N = 18) and in healthy matched control participants (N = 18). Importantly, we used Voxel-Based Morphometry to ensure that our group of patients had a focal unilateral damage restricted to the hippocampus and especially its medial part. We found a clear deficit for target processing at the behavioral level. In addition, compared to controls, our group of patients presented (i) a reduction of theta event-related synchronization (ERS) for targets and (ii) a reduction and delayed P3a source accompanied by reduced theta and low-beta ERS and alpha event-related synchronization (ERD) for novel stimuli. These results suggest that the integrity of the hippocampus might be crucial for the functioning of the complex cortico-subcortical network involved in the detection of novel and target stimuli. |
Subject(s):
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-Hipocamp (Cervell) -Percepció auditiva -Cognició -Atenció -Hippocampus (Brain) -Auditory perception -Cognition -Attention |
Rights:
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cc-by (c) Vilà-Balló, Adrià et al., 2017
http://creativecommons.org/licenses/by/3.0/es |
Document type:
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Article Article - Published version |
Published by:
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Nature Publishing Group
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