Title:
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Early age exposure to moisture damage and systemic inflammation
at the age of 6 years
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Author:
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Karvonen, Anne M.; Tischer, Christina; Kirjavainen, P. V.; Roponen, M.; Hyvarinen, A.; Illi, S.; Mustonen, K.; Pfefferle, P. I.; Renz, H.; Remes, S.; Schaub, B.; Mutius, E. von; Pekkanen, J.
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Abstract:
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Cross-sectional studies have shown that exposure to indoor
moisture damage and mold may be associated with subclinical
inflammation. Our aim was to determine whether early age
exposure to moisture damage or mold is prospectively associated
with subclinical systemic inflammation or with immune
responsiveness in later childhood. Home inspections were
performed in children's homes in the first year of life. At age
6 years, subclinical systemic inflammation was measured by serum
C-reactive protein(CRP) and blood leucocytes and immune
responsiveness by ex vivo production of interleukin
1-beta(IL-1beta), IL-6 and tumor necrosis
factor-alpha(TNF-alpha) in whole blood cultures without
stimulation or after 24h stimulation with phorbol 12-myristate
13-acetate and ionomycin(PI), lipopolysaccharide(LPS) or
peptidoglycan(PPG) in 251 to 270 children. Moisture damage in
child's main living areas in infancy was not significantly
associated with elevated levels of CRP or leucocytes at 6 years.
In contrast, there was some suggestion for an effect on immune
responsiveness, as moisture damage with visible mold was
positively associated with LPS-stimulated production of
TNF-alpha and minor moisture damage was inversely associated
with PI-stimulated IL-1beta. While early life exposure to mold
damage may have some influence on later immune responsiveness,
it does not seem to increase subclinical systemic inflammation
in later life. This article is protected by copyright. All
rights reserved. |
Subject(s):
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-Infants -Citoquines -Children -Cytokines |
Rights:
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cc by-nc-nd (c) Wiley-VCH, 2018
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Document type:
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Article Article - Published version |
Published by:
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Wiley-VCH
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