Títol:
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Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure.
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Autor/a:
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Moncunill, Gemma; Mayor Aparicio, Alfredo Gabriel; Jiménez, Alfons; Nhabomba, Augusto; Puyol, Laura; Manaca, Maria Nélia; Barrios, Diana; Cisteró, Pau; Guinovart, Caterina; Aguilar, Ruth; Bardají, Azucena; Pinazo, María Jesús; Angov, Evelina; Dutta, Sheetij; Chitnis, Chetan E.; Muñoz, José; Gascón i Brustenga, Joaquim; Dobaño, Carlota, 1969-
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Abstract:
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Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n = 48), European adults (naïve travelers, n = 22; expatriates with few prior malaria exposures, n = 15) and Mozambican adults with long-life malaria exposure (n = 99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-142 (P = 0.030) and a P. falciparum isolate (P = 0.002), as well as higher IL-12 (P = 0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ (P≤0.0090), IL-2 (P≤0.0379) and IL-8 (P≤0.0233). Children also had higher IL-12 (P = 0.0001), IL-4 (P = 0.003), IL-1β (P = 0.024) and TNF (P = 0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A TH1/pro-inflammatory response was the hallmark of non-immune subjects. |
Matèries:
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-Citoquines -Malària -Plasmodium falciparum -Cytokines -Malaria -Plasmodium falciparum |
Drets:
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cc-by (c) Moncunill, Gemma et al., 2013
http://creativecommons.org/licenses/by/3.0/es |
Tipus de document:
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Article Article - Versió publicada |
Publicat per:
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Public Library of Science (PLoS)
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Compartir:
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