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Título:	Study of the effect of the chromophore and nuclearity on the aggregation and potential biological activity of gold(I) alkynyl complexes
Autor/a:	Gavara, Raquel; Aguilo, Elisabet; Schur, Julia; Llorca Piqué, Jordi; Ott, Ingo; Rodríguez Raurell, Laura
Otros autores:	Universitat Politècnica de Catalunya. Institut de Tècniques Energètiques; Universitat Politècnica de Catalunya. NEMEN - Nanoenginyeria de materials aplicats a l'energia
Abstract:	The synthesis and characterization of four organometallic gold(I) complexes containing different water soluble phosphanes (TPPTS, PTA and DAPTA) and chromophoric units (4-pyridylethynyl and propargyloxycoumarin) is here reported. The analysis of their absorption and emission spectra led us to attribute their luminescent behavior to the chromophoric organic ligands. Moreover, the presence of the gold(I) metal atom has been observed to be the responsible of an efficient intersystem crossing process responsible for the observed phosphorescence emission. Broad emission bands are observed in most cases due to the formation of organized aggregates in solution in agreement with microscopic characterization.; Biological activity of the complexes showed very low effects against tumor cell growth but an inhibitory potency against thioredoxin reductase (TrxR). The missing/low cytotoxic effects could be related to a low bioavailability as determined by atomic absorption spectroscopy. (C) 2016 Elsevier B.V. All rights reserved.
Materia(s):	-Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Medicina interna -Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Farmacologia -Àrees temàtiques de la UPC::Enginyeria química::Química inorgànica -Molecular pharmacology -Gold -Alkynyl -Thioredoxin reductase -Cytotoxicity -Luminescence -Antitumor-activity -Carbene complexes -In-vitro -Cytotoxicity -derivatives -Inhibition -Mechanisms -Drugs -Farmacologia molecular
Derechos:	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Tipo de documento:	Artículo - Versión presentada Artículo
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