Title:
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Acentrosomal microtubule assembly in mitosis: the where, when, and how
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Author:
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Meunier, Sylvain; Vernos, Isabelle, 1959-
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Abstract:
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In mitosis the cell assembles the bipolar spindle, a microtubule (MT)-based apparatus that segregates the duplicated chromosomes into two daughter cells. Most animal cells enter mitosis with duplicated centrosomes that provide an active source of dynamic MTs. However, it is now established that spindle assembly relies on the nucleation of acentrosomal MTs occurring around the chromosomes after nuclear envelope breakdown, and on pre-existing microtubules. Where chromosome-dependent MT nucleation occurs, when MT amplification takes place and how the two pathways function are still key questions that generate some controversies. We reconcile the data and present an integrated model accounting for acentrosomal microtubule assembly in the dividing cell. |
Abstract:
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This work was supported by the Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013-2017’, SEV-2012-0208. Work in the laboratory of I.V. is supported by the Spanish Ministry of Economy and Competitiveness (grant BFU2012-37163) |
Subject(s):
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-Microtúbuls -- Metabolisme -Mitosi -- Fisiologia |
Rights:
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© Elsevier http://dx.doi.org/10.1016/j.tcb.2015.09.001 |
Document type:
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Article Article - Accepted version |
Published by:
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Elsevier
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