Title:
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PARP-1 and PARP-2 activity in cancer-induced cachexia: potential therapeutic implications
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Author:
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Barreiro Portela, Esther; Gea Guiral, Joaquim
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Abstract:
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Skeletal muscle dysfunction and mass loss is a characteristic feature in patients with chronic diseases including cancer and acute conditions such as critical illness. Maintenance of an adequate muscle mass is crucial for the patients' prognosis irrespective of the underlying condition. Moreover, aging-related sarcopenia may further aggravate the muscle wasting process associated with chronic diseases and cancer. Poly(adenosine diphosphate-ribose) polymerase (PARP) activation has been demonstrated to contribute to the pathophysiology of muscle mass loss and dysfunction in animal models of cancer-induced cachexia. Genetic inhibition of PARP activity attenuated the deleterious effects seen on depleted muscles in mouse models of oncologic cachexia. In the present minireview the mechanisms whereby PARP activity inhibition may improve muscle mass and performance in models of cancer-induced cachexia are discussed. Specifically, the beneficial effects of inhibition of PARP activity on attenuation of increased oxidative stress, protein catabolism, poor muscle anabolism and mitochondrial content and epigenetic modulation of muscle phenotype are reviewed in this article. Finally, the potential therapeutic strategies of pharmacological PARP activity inhibition for the treatment of cancer-induced cachexia are also being described in this review. |
Abstract:
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CIBERES, FIS 14/00713 (PEDER), SAF-2014-54371-R, SEPAR 2016, and FUCAP 2016 (Spain) have contributed to support part of the research described in this review. |
Subject(s):
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-Biological events -Muscle mass loss -Oncologic cachexia -PARP-1 and PARP-2 activity -Skeletal muscles |
Rights:
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info:eu-repo/semantics/embargoedAccess
© De Gruyter Published version available at http://doi.org/10.1515/hsz-2017-0158 |
Document type:
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Article Article - Published version |
Published by:
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De Gruyter
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