Títol:
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Exploring mechanisms of spontaneous functional connectivity in MEG:/nHow delayed network interactions lead to structured amplitude/nenvelopes of band-pass filtered oscillations
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Autor/a:
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Cabral, Joana R. B.; Luckhoo, Henry; Woolrich, Mark; Joensson, Morten; Mohseni, Hamid; Baker, Adam; Kringelbach, Morten L.; Deco, Gustavo
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Abstract:
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Spontaneous (or resting-state) brain activity has attracted a growing body of neuroimaging research over the last/ndecades.Whole-brain networkmodels have proved helpful to investigate the source of slow(b0.1 Hz) correlated/nhemodynamic fluctuations revealed in fMRI during rest. However, the mechanisms mediating resting-state/nlong-distance correlations and the relationship with the faster neural activity remain unclear. Novel insights/ncoming from MEG studies have shown that the amplitude envelopes of alpha- and beta-frequency oscillations/n(8–30 Hz) display similar correlation patterns as the fMRI signals./nIn thiswork, we combine experimental and theoreticalwork to investigate the mechanisms of spontaneousMEG/nfunctional connectivity. Using a simple model of coupled oscillators adapted to incorporate realisticwhole-brain/nconnectivity and conduction delays, we explore how slow and structured amplitude envelopes of band-pass/nfiltered signals – fairly reproducing MEG data collected from 10 healthy subjects at rest – are generated spontaneously/nin the space-time structure of the brain network./nOur simulation results show that the large-scale neuroanatomical connectivity provides an optimal network/nstructure to support a regimewith metastable synchronization. In this regime, different subsystems may temporarily/nsynchronize at reduced collective frequencies (falling in the 8–30 Hz range due to the delays) while the/nglobal system never fully synchronizes. This mechanism modulates the frequency of the oscillators on a slow/ntime-scale (b0.1 Hz) leading to structured amplitude fluctuations of band-pass filtered signals. Taken overall,/nour results reveal that the structured amplitude envelope fluctuations observed in resting-state MEG data may/noriginate from spontaneous synchronization mechanisms naturally occurring in the space-time structure of/nthe brain. |
Abstract:
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The research reported herein was supported by the ERC Advanced/nGrant: DYSTRUCTURE (n. 295129), by the FET Flagship Human Brain/nProject, by the Spanish Research Project SAF2010-16085, by the/nCONSOLIDER-INGENIO 2010 CSD2007-00012, by the BrainNRG through/nthe James S. McDonnell Foundation, by the FP7-ICT BrainScales, by the/nRCUK Digital Economy – Centre for Doctoral Training in Healthcare/nInnovation, by theMINDLab Investment Capital for University Research/nFund and by the TrygFonden Charitable Foundation. |
Matèries:
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-Resting state -MEG -Oscillations -Network -Kuramoto -Modeling -Structural connectivity -Functional connectivity |
Drets:
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© 2013 The Authors. Published by Elsevier Inc. Open access under CC-BY-NC-ND License
http://creativecommons.org/licenses/by-nc-nd/3.0/ |
Tipus de document:
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Article Article - Versió publicada |
Publicat per:
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Elsevier
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