Title:
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Assessment of haemodynamic remodeling in fetal aortic coarctation using a lumped model of the circulation
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Author:
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Giménez Mínguez, Paula; Bijnens, Bart; Bernardino Perez, Gabriel; Lluch Alvarez, Èric; Soveral, Iris; Gómez, Olga; García Cañadilla, Patricia, 1985-
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Abstract:
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Comunicació presentada a: the 9th International Conference Functional Imaging and Modelling of the Heart FIMH 2017, celebrat de l'11 al 13 de juny de 2017 a Toronto, Canadà. |
Abstract:
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Introduction: Aortic coarctation is one of the most difficult cardiac
defects to diagnose before birth, and it accounts for 8% of congenital heart
diseases. Antenatal diagnosis is crucial for early treatment of the neonate and to
decrease the risk of morbidity and mortality; however the fetal hemodynamic
changes are not fully understood and current imaging methods are limited to
accurately diagnosis this congenital defect. Objective: We propose to use a
lumped model of the fetal circulation to provide insights into the hemodynamic
changes in fetuses with aortic coarctation, and thus helping to improve its
diagnosis. Methods: To achieve this goal a patient-specific lumped model of
the fetal circulation was implemented in OpenCOR, including the modeling of
different types and degrees of aortic coarctation. A parametric study of degree
and type of coarctation was performed, where blood flow distribution, cerebroplacental
ratio, pressure drop over the coarctation and left ventricular pressure
were quantified. Results: Obvious changes in the fetal hemodynamics were
observed only from 80% of coarctation, corresponding to the clinically used cutoff
for pressure drop of 20 mmHg. Furthermore, the observed hemodynamic
changes were different depending on the location and degree of the coarctation. |
Abstract:
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This study was partially supported by the Spanish Ministry of Economy and Competitiveness (grant TIN2014-52923-R; Maria de Maeztu Units of Excellence Programme - MDM-2015-0502), FEDER and the European Union Horizon 2020 Programme for Research and Innovation, under grant agreement No. 642676 (CardioFunXion). |
Subject(s):
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-Fetal circulation -Modeling -Aortic coarctation |
Rights:
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© Springer The final publication is available at Springer via
http://dx.doi.org/10.1007/978-3-319-59448-4_45 |
Document type:
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Conference Object Article - Accepted version |
Published by:
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Springer
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