Title:
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Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain
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Author:
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Ardanuy Tisaire, María Carmen; Campa, Adela G. de la; García, Ernesto; Fenoll, Asunción; Calatayud, Laura; Cercenado, Emilia; Pérez Trallero, Emilio; Bouza, Emilio; Liñares Louzao, Josefina
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Abstract:
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Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC ≥16 μg/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug-susceptible serotype 8-ST53 isolates. Serotype 8-ST63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invasive disease in Spain. |
Subject(s):
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-Pneumococs -Infeccions per pneumococs -Estreptococs -Resistència als medicaments -Malalties de l'aparell respiratori -Malalties infeccioses -Espanya -Streptococcus pneumonia -Pneumococcal Infections -Streptococcus -Drug resistance -Respiratory organs diseases -Communicable diseases -Spain |
Rights:
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Domini públic / Public domain
http://creativecommons.org/publicdomain/zero/1.0/ |
Document type:
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Article Article - Published version |
Published by:
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Centers for Disease Control and Prevention
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