Title:
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Iron catalyzed highly enantioselective epoxidation of cyclic aliphatic enones with aqueous H2O2
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Author:
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Cussó Forest, Olaf; Cianfanelli, Marco; Ribas Salamaña, Xavi; Klein Gebbink, Robertus J M; Costas Salgueiro, Miquel
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Other authors:
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Ministerio de Economía y Competitividad (Espanya); Ministerio de Ciencia e Innovación (Espanya); Generalitat de Catalunya. Agència de Gestió d'Ajuts Universitaris i de Recerca |
Abstract:
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An iron complex with a C1-symmetric tetradentate N-based ligand catalyzes the asymmetric epoxidation of cyclic enones and cyclohexene ketones with aqueous hydrogen peroxide, providing the corresponding epoxides in good to excellent yields and enantioselectivities (up to 99% yield, and 95% ee), under mild conditions and in short reaction times. Evidence is provided that reactions involve an electrophilic oxidant, and this element is employed in performing site selective epoxidation of enones containing two alkene sites |
Abstract:
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We acknowledge financial support from European Research Council (ERC‐2009‐StG‐239910), MINECO of Spain (CTQ2012‐37420‐C02‐01/BQU, Consolider‐Ingenio CSD2010‐00065) and the Catalan DIUE of the Generalitat de Catalunya (2009SGR637) |
Subject(s):
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-Epòxids -Epoxy compounds -Catalitzadors -Catalysts -Ferro -- Oxidació -Iron -- Oxidation -Catàlisi asimètrica -Enantioselective catalysis |
Rights:
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Tots els drets reservats
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Document type:
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Article Article - Accepted version |
Published by:
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American Chemical Society (ACS)
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