An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies

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Title:	An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies
Author:	Gandioso, Albert; Shaili, Evyenia; Massaguer i Vall-llovera, Anna; Artigas, Gerard; González-Cantó, Alejandro; Woods, Julie A.; Sadler, Evyenia; Marchán, Vicente
Abstract:	A new anticancer agent based on the conjugation of a photoactivatable Pt(iv) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing αVβ3 integrin compared to control DU-145 human prostate carcinoma cells
Subject(s):	-Medicaments antineoplàstics -Antineoplastic agents
Rights:	Attribution 3.0 Spain http://creativecommons.org/licenses/by/3.0/es/
Document type:	Article Article - Published version
Published by:	Royal Society of Chemistry (RSC)
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