Title:
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Hippeastrum reticulatum (Amaryllidaceae): Alkaloid profiling, biological activities and molecular docking
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Author:
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Tallini, Luciana R.; Osorio, Edison H.; Dias dos Santos, Vanessa; Souza Borges, Warley de; Kaiser, Marcel; Viladomat Meya, Francesc; Zuanazzi, José Ângelo Silveira; Bastida Armengol, Jaume
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Other authors:
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Universitat de Barcelona |
Abstract:
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The Amaryllidaceae family has proven to be a rich source of active compounds, which are characterized by unique skeleton arrangements and a broad spectrum of biological activities. The aim of this work was to perform the first detailed study of the alkaloid constituents of Hippeastrum reticulatum (Amaryllidaceae) and to determine the anti-parasitological and cholinesterase (AChE and BuChE) inhibitory activities of the epimers (6α-hydroxymaritidine and 6β-hydroxymaritidine). Twelve alkaloids were identified in H. reticulatum: eight known alkaloids by GC-MS and four unknown (6α-hydroxymaritidine, 6β-hydroxymaritidine, reticulinine and isoreticulinine) by NMR. The epimer mixture (6α-hydroxymaritidine and 6β-hydroxymaritidine) showed low activity against all protozoan parasites tested and weak AChE-inhibitory activity. Finally, a molecular docking analysis of AChE and BuChE proteins showed that isoreticulinine may be classified as a potential inhibitory molecule since it can be stabilized in the active site through hydrogen bonds, π-π stacking and hydrophobic interactions. |
Subject(s):
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-Plantes bulboses -Alcaloides -Bulb plants -Alkaloids |
Rights:
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cc-by (c) Tallini, Luciana R. et al., 2017
http://creativecommons.org/licenses/by/3.0/es |
Document type:
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Article Article - Published version |
Published by:
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MDPI
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