Title:
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Scaling the microrheology of living cells
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Author:
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Fabry, Ben; Maksym, Geoffrey N.; Butler, James P.; Glogauer, Michael; Navajas Navarro, Daniel; Fredberg, Jeffrey J.
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Other authors:
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Universitat de Barcelona |
Abstract:
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We report a scaling law that governs both the elastic and frictional properties of a wide variety of living cell types, over a wide range of time scales and under a variety of biological interventions. This scaling identifies these cells as soft glassy materials existing close to a glass transition, and implies that cytoskeletal proteins may regulate cell mechanical properties mainly by modulating the effective noise temperature of the matrix. The practical implications are that the effective noise temperature is an easily quantified measure of the ability of the cytoskeleton to deform, flow, and reorganize. |
Subject(s):
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-Física mèdica -Equacions d'estat -Regla de les fases i equilibri -Medical physics -Equations of state -Phase rule and equilibrium |
Rights:
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(c) The American Physical Society, 2001
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Document type:
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Article Article - Published version |
Published by:
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The American Physical Society
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