dc.contributor.author |
Gutierrez, Humberto |
dc.contributor.author |
Hale, Valerie A. |
dc.contributor.author |
Dolcet Roca, Xavier |
dc.contributor.author |
Davies, Alun M. |
dc.date |
2015-11-19T13:03:20Z |
dc.date |
2015-11-19T13:03:20Z |
dc.date |
2005-04 |
dc.identifier |
0950-1991 |
dc.identifier |
http://hdl.handle.net/10459.1/49010 |
dc.identifier |
https://doi.org/10.1242/dev.01702 |
dc.identifier.uri |
http://hdl.handle.net/10459.1/49010 |
dc.description |
The proper growth and elaboration of neural processes is essential for the establishment of a functional nervous system during development and is an integral feature of neural plasticity throughout life. Nuclear factor-kappa B (NF-kappa B) is classically known for its ubiquitous roles in inflammation, immune and stress-related responses and regulation of cell survival in all tissues, including the nervous system. NF-kappa B participation in other cellular processes remains poorly understood. Here we report a mechanism for controlling the growth of neural processes in developing peripheral and central neurons involving the transcription factor NF-kappa B. Inhibiting NF-kappa B activation with super-repressor I kappa B-alpha, BAY 11 7082 (I kappa B-alpha phosphorylation inhibitor) or N-acetyl-Leu-Leu-norleucinal (proteosomal degradation inhibitor), or inhibiting NF-kappa B transcriptional activity with kappa B decoy DNA substantially reduced the size and complexity of the neurite arbors of sensory neurons cultured with brain-derived neurotrophic factor while having no effect on their survival. NF-kappa B exerted this effect during a restricted period of development following the phase of naturally occurring neuronal death when the processes and connections of the remaining neurons are extensively modified and refined. Inhibiting NF-kappa B activation or NF-kappa B transcriptional activity in layer 2 pyramidal neurons in postnatal somatosensory cortical slices reduced dendritic arbor size and complexity. This function of NF-kappa B has important implications for neural development and may provide an explanation for reported involvement of NF-kappa B in learning and memory. |
dc.language |
eng |
dc.publisher |
Company of Biologists Ltd. |
dc.relation |
Reproducció del document publicat a https://doi.org/10.1242/dev.01702 |
dc.relation |
Development, 2005, vol. 32, núm. 7, p. 1713-1726 |
dc.rights |
(c) Company of Biologists Ltd., 2005 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
NF-kappa B |
dc.subject |
Axon |
dc.subject |
Dendrite |
dc.subject |
Pyramidal neuron |
dc.subject |
Sensory neuron |
dc.subject |
Neurones sensorials |
dc.subject |
Sistema nerviós |
dc.title |
NF-κB signalling regulates the growth of neural processes in the developing PNS and CNS |
dc.type |
article |
dc.type |
publishedVersion |