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Título:
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Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
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Autor/a:
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Alcubierre Calvo, Núria; Navarrete Muñoz, Eva María; Rubinat, Esther; Falguera, Mireia; Valls Marsal, Joan; Traveset Maeso, Alicia; Vilanova, María-Belén; Marsal Mora, Josep Ramon; Hernández, Marta; Granado Casas, Minerva; Martínez González, María Dolores; Jurjo Campo, Carmen; Franch-Nadal, Josep; Vioque, Jesus; Mauricio Puente, Dídac
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Notas:
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Background: The objective of this study was to describe the intake of macronutrient, especially fatty acids, and
explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus.
Methods: In this case–control study, we included a total of 146 patients with DR and 148 without DR. The intake of
macronutrient was evaluated using a validated food frequency questionnaire. We used logistic regression adjusted
for sex, age, diabetes duration, energy intake, educational level, physical activity, waist circumference, systolic blood
pressure, high-density lipoprotein cholesterol and diabetes treatment, to estimate odds ratio (ORs) of DR.
Results: Patients with DR had significantly lower intake of fibre, monounsaturated fatty acids (MUFA), and palmitic
and oleic acid. Inverse associations were observed between MUFA and oleic acid intake in DR. Subjects with
intermediate and high MUFA intake were less likely to have DR than those with lower MUFA intake, with ORs of 0.
46 (95 % CI: 0.22–0.93) and 0.42 (95 % CI: 0.18–0.97), respectively. Similarly, intermediate and high oleic acid intake
were associated with reduced DR frequency compared with low oleic acid intake, with OR values of 0.48 (95 % CI: 0.
23–0.97) and 0.37 (95 % CI: 0.16–0.85), respectively. These associations were stronger in patients with a longer
diabetes duration.
Conclusion: In type 2 diabetes mellitus, MUFA and oleic acid intake were inversely associated with DR.
This study was supported by grant PS09/01035 from Instituto of Salud Carlos III. N.A holds a predoctoral fellowship from Instituto of Salud Carlos III FI11/ 0008. CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM) is an initiative included in Plan Nacional de I + D + I and cofinanced by Instituto de Salud Carlos III Subdireccion General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER). |
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Materia(s):
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-Diabetic retinopathy
-Oleic acid
-Monounsaturated fatty acids
-Fatty acids |
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Derechos:
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cc-by (c) Alcubierre et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
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Tipo de documento:
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article
publishedVersion |
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Editor:
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BioMed Central
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