dc.contributor.author |
Zhu, Changfu |
dc.contributor.author |
Farré Martinez, Gemma |
dc.contributor.author |
Zanga, Daniela |
dc.contributor.author |
Lloveras Vilamanyà, Jaume |
dc.contributor.author |
Michelena Bárcena, Antonio |
dc.contributor.author |
Ferrio Díaz, Juan Pedro |
dc.contributor.author |
Voltas Velasco, Jordi |
dc.contributor.author |
Slafer, Gustavo A. |
dc.contributor.author |
Savin, Roxana |
dc.contributor.author |
Albajes Garcia, Ramon |
dc.contributor.author |
Eizaguirre Altuna, Matilde |
dc.contributor.author |
López Alonso, Carmen |
dc.contributor.author |
Cantero-Martínez, Carlos |
dc.contributor.author |
Díaz Gómez, Joana |
dc.contributor.author |
Nogareda, Carmina |
dc.contributor.author |
Moreno Martínez, José Antonio |
dc.contributor.author |
Angulo Asensio, Eduardo |
dc.contributor.author |
Estany Illa, Joan |
dc.contributor.author |
Pena i Subirà, Ramona Natacha |
dc.contributor.author |
Tor i Naudí, Marc |
dc.contributor.author |
Portero Otín, Manuel |
dc.contributor.author |
Eritja Sánchez, Núria |
dc.contributor.author |
Arjó Pont, Gemma |
dc.contributor.author |
Serrano Casasola, José Carlos Enrique |
dc.contributor.author |
Matias-Guiu, Xavier |
dc.contributor.author |
Twyman, Richard M. |
dc.contributor.author |
Sandmann, Gerhard |
dc.contributor.author |
Capell Capell, Teresa |
dc.contributor.author |
Christou, Paul |
dc.date |
2018-01-23T13:12:21Z |
dc.date |
2018-06-03T22:24:48Z |
dc.date |
2017-06-01 |
dc.date |
2018-01-23T13:12:22Z |
dc.identifier |
1568-7767 |
dc.identifier |
http://hdl.handle.net/10459.1/62539 |
dc.identifier |
https://doi.org/10.1007/s11101-017-9506-4 |
dc.identifier.uri |
http://hdl.handle.net/10459.1/62539 |
dc.description |
Carolight® is a transgenic maize variety that accumulates extraordinary levels of carotenoids, including those with vitamin A activity. The development of Carolight® maize involved the technical implementation of a novel combinatorial transformation method, followed by rigorous testing for transgene expression and the accumulation of different carotenoid molecules. Carolight® was envisaged as a way to improve the nutritional health of human populations that cannot access a diverse diet, but this ultimate humanitarian application can only be achieved after extensive testing for safety, agronomic performance and nutritional sufficiency. In this article, we chart the history of Carolight® maize focusing on its development, extensive field testing for agronomic performance and resistance to pests and pathogens, and feeding trials to analyze its impact on farm animals (and their meat/dairy products) as well as animal models of human diseases. We also describe more advanced versions of Carolight® endowed with pest-resistance traits, and other carotenoid-enhanced maize varieties originating from the same series of initial transformation experiments. Finally we discuss the further steps required before Carolight® can fulfil its humanitarian objectives, including the intellectual property and regulatory constraints that lie in its path. |
dc.description |
European Research Council Advanced Grant (BIOFORCE) and Proof of Concept Grant (Multinutrient Maize) to PC; Spanish Ministry of Economy and Competitiveness (AGL2014-53970-C2-1-R, AGL2015-65846-R, BIO2014-54426-P and BIO2014-54441-P); RecerCaixa project PC084082; Catalan Autonomous Community 2014 SGR 1296 Agricultural Biotechnology Research Group and Agrotecnio Research Center. JDG thanks the UdL for a Ph.D. fellowship. |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
Springer Verlag |
dc.relation |
MINECO/PN2013-2016/AGL2014-53970-C2-1-R |
dc.relation |
MINECO/PN2013-2016/AGL2015-65846-R |
dc.relation |
MINECO/PN2013-2016/BIO2014-54441-P |
dc.relation |
MINECO/PN2013-2016/BIO2014-54426-P |
dc.relation |
Versió postprint del document publicat a https://doi.org/10.1007/s11101-017-9506-4 |
dc.relation |
Phytochemistry Reviews, 2017, p. 1-15 |
dc.relation |
info:eu-repo/grantAgreement/EC/FP7/232933 |
dc.rights |
(c) Springer Science+Business Media, 2017 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Maize |
dc.subject |
Carotenoid |
dc.subject |
Poultry production |
dc.subject |
Egg production |
dc.subject |
Trout feeding |
dc.title |
High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition |
dc.type |
info:eu-repo/semantics/article |
dc.type |
acceptedVersion |