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Título:
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Genetic markers associated with field PRRSV-induced abortion rates
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Autor/a:
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Pena i Subirà, Ramona Natacha; Fernández, Carlos; Blasco-Felip, María; Fraile Sauce, Lorenzo José; Estany Illa, Joan
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Notas:
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In gilts and sows, the more severe clinical manifestation of PRRSV occurs in late gestation and can result in up to 40% of abortion incidence. Despite the known genetic component in the resilience to PRRSV, there is scarce information regarding the abortive outcome of this disease. We have tested the relationship between eight molecular markers (six from published studies and two identified in the present study in the HDAC6 gene) and the probability of abortion during a PRRSV outbreak, using data of two commercial Landrace x Large White sow farms with an incidence of abortion of 35% and 17%. From the markers tested, the USP18_-1533G>A did not segregate in these populations and CD163_c.3534C>T and HDAC6_g.2360C>T did not affect abortion rate. In contrast, the minor allele of two markers in SSC4 (WUR1000125 in GBP1 and rs340943904 in GBP5), which lower viremia in growing pigs, and the major alleles of CD163_rs1107556229 and HDAC6_rs325981825 were associated with lower probability of abortion during PRRSV outbreaks. The more striking result was for the MX1 gene, where odds ratio of aborting vs not was 9 times lower in the sows homozygous for a 275bp insertion than in the other genotypes. Interactions between markers were not relevant. All together, we bring here the first evidence that mutations in the host genome can predispose or protect from complete reproductive failure in sows infected with PRRSV.
This research and the APC were partially funded by FEDER projects COMRDI16-1-0035-03 and
RTI2018-097700-B-I00 from the Spanish Ministry of Science, Innovation, and Universities. |
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Materia(s):
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-PRRS
-DNA markers
-Abortion rate
-Transplacental infection |
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Derechos:
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cc-by (c) Pena i Subirà, Ramona Natacha et al., 2019
https://creativecommons.org/licenses/by/4.0/
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Tipo de documento:
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Artículo
Artículo - Versión publicada |
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Editor:
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MDPI
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Compartir:
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