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Title:
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HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
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Author:
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Izquierdo Useros, Nuria; Lorizate, M.; McLaren, P.J.; Telenti, Amalio; Kräusslich, H.G.; Martinez Picado, Francisco Javier
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Other authors:
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Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades |
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Notes:
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Dendritic cells (DCs) are essential in order to
combat invading viruses and trigger antiviral responses.
Paradoxically, in the case of HIV-1, DCs might contribute
to viral pathogenesis through trans-infection, a mechanism
that promotes viral capture and transmission to
target cells, especially after DC maturation. In this review,
we highlight recent evidence identifying sialyllactosecontaining
gangliosides in the viral membrane and the
cellular lectin Siglec-1 as critical determinants for HIV-1
capture and storage by mature DCs and for DC-mediated
trans-infection of T cells. In contrast, DC-SIGN, long
considered to be the main receptor for DC capture of
HIV-1, plays a minor role in mature DC-mediated HIV-1
capture and trans-infection. |
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Subject(s):
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-Sida -- Tractament |
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Rights:
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Aquest document està subjecte a aquesta llicència Creative Commons
http://creativecommons.org/licenses/by/3.0/es/
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Document type:
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Article
info:eu-repo/acceptedVersion |
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Published by:
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Public Library of Science
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