Title:
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BMP8 and activated brown adipose tissue in human newborns
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Author:
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Urisarri, Adela; González-García, Ismael; Estévez-Salguero, Ánxela; Pata, María P.; Milbank, Edward; López, Noemi; Mandiá, Natalia; Grijota-Martinez, Carmen; Salgado, Carlos A.; Nogueiras, Rubén; Diéguez, Carlos; Villarroya, Francesc; Fernández-Real, Jose Manuel; Couce, Maria Luz; López, Miguel
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Other authors:
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Institut Català de la Salut; [Urisarri A, López N, Mandiá N] Neonatology Service, Department of Pediatrics, University Clinical Hospital of Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), CIBER Enfermedades Raras (CIBERER), Travesia Choupana, Santiago de Compostela, Spain. [González-García I, Estévez-Salguero A, Milbank E, Nogueiras R, Diéguez C] Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain. [Pata MP] Biostatech Advice, Training and Innovation in Biostatistics, S.L. Santiago de Compostela, Spain. [Grijota-Martinez C] Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain. [Salgado CA] Instituto Galego de Física de Altas Enerxías (IGFAE), University of Santiago de Compostela, Santiago de Compostela, Spain. [Villarroya F] CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain. Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina, Universitat de Barcelona (IBUB), and Institut de Recerca Hospital Sant Joan de Déu, Barcelona, Spain. [Fernández-Real JM] CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain. Institut d'Investigació Biomèdica de Girona (IDIBGI),Salt, Spain. Department de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, Girona, Spain. Departament de Diabetes, Endocrinologia i Nutrició (UDEN), Hospital Universitari de Girona Dr. Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain. [Couce ML] Neonatology Service, Department of Pediatrics, University Clinical Hospital of Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), CIBER Enfermedades Raras (CIBERER), Travesia Choupana, Santiago de Compostela, Spain. [López M] Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Hospital Universitari de Girona Dr Josep Trueta |
Abstract:
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Tejido adiposo marrón; Neonatología; Proteina morfogenética ósea |
Abstract:
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Teixit adipós marró; Pes neonatal; Proteïna morfogenètica òssia |
Abstract:
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Brown adipose tissue; Birth weight; Bone morphogenetic proteins |
Abstract:
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The classical dogma states that brown adipose tissue (BAT) plays a major role in the regulation of temperature in neonates. However, although BAT has been studied in infants for more than a century, the knowledge about its physiological features at this stage of life is rather limited. This has been mainly due to the lack of appropriate investigation methods, ethically suitable for neonates. Here, we have applied non-invasive infrared thermography (IRT) to investigate neonatal BAT activity. Our data show that BAT temperature correlates with body temperature and that mild cold stimulus promotes BAT activation in newborns. Notably, a single short-term cold stimulus during the first day of life improves the body temperature adaption to a subsequent cold event. Finally, we identify that bone morphogenic protein 8B (BMP8B) is associated with the BAT thermogenic response in neonates. Overall, our data uncover key features of the setup of BAT thermogenesis in newborns |
Abstract:
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The research leading to these results hasreceived funding from the Xunta de Galicia (R.N.: 2016-PG057; M.L.: 2016-PG068);Ministerio de Economía y Competitividad (MINECO) co-funded by the FEDER Pro-gram of EU (R.N.: RTI2018-099413-B-I00; C.D.: BFU2017-87721-P; F.V.: SAF2017-85722-R; M.L.: RTI2018-101840-B-I00: F.V., J.M.F.-R., and M.L.: BFU2017-90578-REDT/Adipoplast); Instituto de Salud Carlos III (J.M.F.-R.: PI15-01934); AtresmediaCorporación (R.N. and M.L.); Fundación BBVA (R.N.); la Caixa Foundation (ID100010434), under the agreement LCF/PR/HR19/52160022 (M.L.); European Founda-tion for the Study of Diabetes (R.N.) and ERC Synergy Grant-2019-WATCH- 810331(R.N.) and Research Grant SOPEGA 2016 (A.U. and M.L.C.). F.V. is an ICREA Aca-demia researcher (Generalitat de Catalunya). I.G.-G. is the recipient of a fellowship fromthe European Union’s Horizon 2020 research and innovation program under the MarieSklodowska-Curie actions. The CiMUS is supported by the Xunta de Galicia (2016-2019,ED431G/05). CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative ofISCIII. The funders had no role in study design, data collection, and analysis, decision topublish, or preparation of the paper. |
Subject(s):
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-Teixit adipós -Temperatura corporal - Control -Infants nounats -ANATOMY::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, Brown -DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Birth Weight -ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Vital Signs::Body Temperature -NAMED GROUPS::Persons::Age Groups::Infant::Infant, Newborn -ANATOMÍA::tejidos::tejido conectivo::tejido adiposo::grasa parda -ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::peso corporal::peso al nacer -TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::exploración física::signos vitales::temperatura corporal -DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::lactante::recién nacido |
Rights:
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Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
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Document type:
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Article Article - Published version |
Published by:
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Nature Publishing Group
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