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Title:	Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded nanoparticles: toward new osseointegrative therapies
Author:	Rocas, Pau; Hoyos Nogués, Mireia; Rocas, Josep; Manero Planella, José María; Gil Mur, Francisco Javier; Albericio Palomera, Fernando; Mas Moruno, Carlos
Notes:	A novel class of polyurethane-polyurea nanoparticles (PUUa NPs) to install multifunctionality on biomaterials is presented. Biofunctionalization of titanium with roxithromycin loaded RGD-decorated PUUa NPs results in an outstanding improvement of osteoblast adhesion and strong suppression of bacterial attachment. This strategy represents a powerful approach to enhance the osseointegration of implant materials.
Subject(s):	-Titani -Materials biomèdics -Implants -Materials nanoestructurats -Pèptids -Titanio -Materiales biomédicos -Implantes -Materiales nanoestructurados -Péptidos -Titanium -Biomedical materials -Implants -Nanostructured materials -Peptides -61
Rights:	This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifi cations or adaptations are made. https://creativecommons.org/licenses/by-nc-nd/4.0/
Document type:	Article Article - Accepted version
Published by:	Wiley
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