Título:
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Inhibitors of the M2 channel of influenza A virus
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Autor/a:
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Duque, María D.; Torres, Eva; Valverde, Elena; Barniol-Xicota, Marta; Guardiola Bagán, Salvador; Rey Carrizo, Matías; Vázquez Cruz, Santiago
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Otros autores:
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Universitat de Barcelona |
Abstract:
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Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392 |
Abstract:
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Influenza is a highly contagious, major respiratory tract disease affecting millions of people each year. At present, two classes of antivirals are available: the neuraminidase inhibitors and the M2 proton channel blockers amantadine and rimantadine. However, rapid emergence of M2 blockers resistance makes imperative the development of new anti-influenza drugs. In the last few years several groups have synthesized and evaluated several analogs of amantadine. While several of them are active against wild-type M2 channel only a few are able to inhibit the mutant ion channels that lead to amantadine-resistance. |
Materia(s):
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-Influenzavirus -Resistència als medicaments -Inhibidors enzimàtics -Influenza viruses -Drug resistance -Enzyme inhibitors |
Derechos:
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(c) Transworld Research Network, 2011
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Tipo de documento:
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Capítulo o parte de libro |
Editor:
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Transworld Research Network
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