Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression.

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dc.contributor	Universitat de Barcelona
dc.contributor.author	Rodríguez García, Marta
dc.contributor.author	Climent, Núria
dc.contributor.author	Oliva, Harold
dc.contributor.author	Casanova Güell, Víctor
dc.contributor.author	Franco Fernández, Rafael
dc.contributor.author	Leon, Agathe
dc.contributor.author	Gatell, José M.
dc.contributor.author	García, Felipe
dc.contributor.author	Gallart, Teresa
dc.date	2013-05-07T09:35:44Z
dc.date	2013-05-07T09:35:44Z
dc.date	2010
dc.date	2013-05-07T09:35:44Z
dc.identifier.citation	1932-6203
dc.identifier.citation	593531
dc.identifier.uri	http://hdl.handle.net/2445/42863
dc.format	10 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Public Library of Science (PLoS)
dc.relation	Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0009436
dc.relation	PLoS One, 2010, vol. 5, num. 2, p. e9436-e9436
dc.relation	http://dx.doi.org/10.1371/journal.pone.0009436
dc.rights	cc-by (c) Rodríguez García, M. et al., 2010
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.subject	VIH (Virus)
dc.subject	Immunologia
dc.subject	HIV (Viruses)
dc.subject	Immunology
dc.title	Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression.
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Defensins are natural endogenous antimicrobial peptides with potent anti-HIV activity and immuno-modulatory effects. We recently demonstrated that immature dendritic cells (DC) produce α-defensins1-3 and that α-defensins1-3 modulate DC generation and maturation. Since DC-HIV interaction plays a critical role during the first steps of HIV infection, we investigated the possible impact of α-defensins1-3 production by DC on disease progression.

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