Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila

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dc.contributor.author	Guigó Serra, Roderic
dc.contributor.author	Blanco, Enrique
dc.contributor.author	Pignatelli, Miguel
dc.contributor.author	Punset, Adrià
dc.contributor.author	Pérez-Lluch, Sílvia
dc.contributor.author	Serras Rigalt, Florenci
dc.contributor.author	Corominas Guiu, Montserrat
dc.date	2008
dc.identifier.citation	Blanco E, Pignatelli M, Beltran S, Punset A, Pérez-Lluch S, Serras F et al. Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila. Genome Biol. 2008; 9(9): 134-134. DOI 10.1186/gb-2008-9-9-r134
dc.identifier.citation	1465-6914
dc.identifier.citation	http://dx.doi.org/10.1186/gb-2008-9-9-r134
dc.identifier.uri	http://hdl.handle.net/10230/6243
dc.description.abstract	BACKGROUND: The trithorax group (trxG) and Polycomb group (PcG) proteins are responsible for the maintenance of stable transcriptional patterns of many developmental regulators. They bind to specific regions of DNA and direct the post-translational modifications of histones, playing a role in the dynamics of chromatin structure. RESULTS: We have performed genome-wide expression studies of trx and ash2 mutants in Drosophila melanogaster. Using computational analysis of our microarray data, we have identified 25 clusters of genes potentially regulated by TRX. Most of these clusters consist of genes that encode structural proteins involved in cuticle formation. This organization appears to be a distinctive feature of the regulatory networks of TRX and other chromatin regulators, since we have observed the same arrangement in clusters after experiments performed with ASH2, as well as in experiments performed by others with NURF, dMyc, and ASH1. We have also found many of these clusters to be significantly conserved in D. simulans, D. yakuba, D. pseudoobscura and partially in Anopheles gambiae. CONCLUSION: The analysis of genes governed by chromatin regulators has led to the identification of clusters of functionally related genes conserved in other insect species, suggesting this chromosomal organization is biologically important. Moreover, our results indicate that TRX and other chromatin regulators may act globally on chromatin domains that contain transcriptionally co-regulated genes.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	BioMed Central
dc.relation	Genome Biology 2008; 9(9): r134
dc.rights	This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/2.0/
dc.subject	Drosòfila -- Genètica
dc.subject	Genètica del desenvolupament
dc.subject	Mutació (Biologia)
dc.subject	Genome studies
dc.subject	Evolution
dc.subject	Model organisms
dc.subject	Drosofila melanogaster
dc.title	Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion

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