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Título:
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Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair.
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Autor/a:
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Puigdellívol Sánchez, Anna; Prats Galino, Alberto; Molander, Carl
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Otros autores:
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Universitat de Barcelona |
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Abstract:
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Peripheral nerve injury is typically associated with long-term disturbances in sensory localization, despite nerve repair and regeneration. Here, we investigate the extent of correct reinnervation by back-labeling neuronal soma with fluorescent tracers applied in the target area before and after sciatic nerve injury and repair in the rat. The subpopulations of sensory or motor neurons that had regenerated their axons to either the tibial branch or the skin of the third hindlimb digit were calculated from the number of cell bodies labeled by the first and/or second tracer. Compared to the normal control side, 81% of the sensory and 66% of the motor tibial nerve cells regenerated their axons back to this nerve, while 22% of the afferent cells from the third digit reinnervated this digit. Corresponding percentages based on quantification of the surviving population on the experimental side showed 91%, 87%, and 56%, respectively. The results show that nerve injury followed by nerve repair by epineurial suture results in a high but variable amount of topographically correct regeneration, and that proportionally more neurons regenerate into the correct proximal nerve branch than into the correct innervation territory in the skin |
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Materia(s):
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-Nervis perifèrics
-Pell
-Neurones motores
-Regeneració del sistema nerviós
-Rates (Animals de laboratori)
-Peripheral nerves
-Skin
-Motor neurons
-Nervous system regeneration
-Rats as laboratory animals |
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Derechos:
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(c) Elsevier B.V., 2006
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Tipo de documento:
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Artículo
Artículo - Versión aceptada |
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Editor:
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Elsevier B.V.
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Compartir:
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