dc.contributor |
Universitat de Barcelona |
dc.contributor.author |
Berzigotti, Annalisa |
dc.contributor.author |
Reverter, Enric |
dc.contributor.author |
García-Criado, Angeles |
dc.contributor.author |
González-Abraldes Iglesias, Juan |
dc.contributor.author |
Cerini, Federica |
dc.contributor.author |
García Pagán, Juan Carlos |
dc.contributor.author |
Bosch i Genover, Jaume |
dc.date |
2014-11-21T09:10:44Z |
dc.date |
2013-05-10 |
dc.date |
2014-11-21T09:10:44Z |
dc.identifier.citation |
0168-8278 |
dc.identifier.citation |
638264 |
dc.identifier.uri |
http://hdl.handle.net/2445/59884 |
dc.format |
27 p. |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Elsevier |
dc.relation |
Versió postprint del document publicat a: http:/dx.doi.org/10.1016/j.jhep.2013.04.037 |
dc.relation |
Journal of Hepatology, 2013, vol. 59, num. 4, p. 717-722 |
dc.relation |
http://dx.doi.org/10.1016/j.jhep.2013.04.037 |
dc.rights |
(c) Elsevier, 2013 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Hipertensió portal |
dc.subject |
Cirrosi hepàtica |
dc.subject |
Ecografia Doppler |
dc.subject |
Portal hypertension |
dc.subject |
Hepatic cirrhosis |
dc.subject |
Doppler ultrasonography |
dc.title |
Reliability of the estimation of total hepatic blood flow by doppler ultrasound in patients with cirrhotic portal hypertension |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/acceptedVersion |
dc.description.abstract |
BACKGROUND & AIMS: Hepatic blood flow (HBF) is best estimated by the Fick's method during indocyanine green constant infusion (ICG-HBF) on hepatic vein catheterization. We investigated the consistency and agreement of HBF measured by Doppler ultrasound (US-HBF) as compared with ICG-HBF in portal hypertensive patients with cirrhosis. METHODS: In 50 patients observed for HVPG measurement (56% compensated; Child score 7 ± 2; HVPG 16.6 ± 6.0 mmHg; varices in 75%) US-HBF (Sequoia-512-Acuson; 4.5-7 MHz convex probe; US-HBF = hepatic artery blood flow+portal vein blood flow) and ICG-HBF (Fick's method after an equilibration period of at least 45 min of ICG bolus of 5 mg + constant rate infusion of 0.2 mg/min). Intraclass correlation coefficient (ICC) for consistency and absolute agreement between US-HBF and ICG-HBF were calculated. RESULTS: Mean ICG-HBF and US-HBF were similar, being respectively 1004 ± 543 ml/min and 994 ± 494 ml/min (p = 0.661 vs. ICG-HBF). However, results in individual patients disclosed marked differences between the two methods (386 ± 415 ml/min) and showed only moderate consistency (ICC 0.456; p < 0.0001), absolute agreement (ICC 0.461; p < 0.0001) and linear correlation (R = 0.464; p < 0.0001). The discrepancy between the two methods was maximal in patients with poor liver function, high HBF by any technique and more arterialized liver circulation. Hepatic artery blood flow ≥40% of US-HBF indicated, with 90% specificity, a discrepancy ≥20% between US-HBF and ICG-HBF. CONCLUSIONS: HBF estimations by Doppler-ultrasound and ICG are significantly correlated, but their discrepancy in individual cases is high. Estimation of HBF by Doppler-US should be considered unreliable in patients with poor hepatic function and large liver arterialization. |