Title:
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Absence of hepatitis delta infection in a large rural HIV cohort
in Tanzania
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Author:
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Winter, Annja; Letang, Emilio; Kalinjuma, Aneth Vedastus; Kimera, Namvua; Ntamatungiro, Alex J.; Glass, Tracy R.; Moradpour, Darius; Sahli, Roland; Le Gal, Frédéric; Furrer, Hansjakob; Wandeler, Gilles; KIULARCO Study Group
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Abstract:
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OBJECTIVES: The epidemiological and clinical determinants of
hepatitis delta virus (HDV) infection in Sub-Saharan Africa are
ill-defined. The prevalence of HDV infection was determined in
HIV/hepatitis B virus (HBV) co-infected individuals in rural
Tanzania. METHODS: All hepatitis B virus (HBV)-infected adults
under active follow-up in the Kilombero and Ulanga
Antiretroviral Cohort (KIULARCO) were screened for anti-HDV
antibodies. For positive samples, a second serological test and
nucleic acid amplification were performed. Demographic and
clinical characteristics at initiation of antiretroviral therapy
(ART) were compared between anti-HDV-negative and positive
patients. RESULTS: Among 222 HIV/HBV co-infected patients on
ART, 219 (98.6%) had a stored serum sample available and were
included in the study. Median age was 37 years, 55% were female,
46% had World Health Organization stage III/IV HIV disease, and
the median CD4 count was 179 cells/mul. The prevalence of
anti-HDV positivity was 5.0% (95% confidence interval 2.8-8.9%).
There was no significant predictor of anti-HDV positivity. HDV
could not be amplified in any of the anti-HDV-positive patients
and the second serological test was negative in all of them.
CONCLUSIONS: No confirmed case of HDV infection was found among
over 200 HIV/HBV co-infected patients in Tanzania. As
false-positive serology results are common, screening results
should be confirmed with a second test. |
Subject(s):
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-VIH (Virus) -Virus de l'hepatitis delta -HIV (Viruses) -Hepatitis D (hepatitis delta) |
Rights:
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cc by-nc-nd (c) Winter et al., 2016
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Document type:
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Article Article - Published version |
Published by:
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Elsevier Inc.
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