Title:
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Easy introduction of maleimides at different positions of oligonucleotide chains for conjugation purposes
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Author:
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Sánchez, Albert; Pedroso Muller, Enrique; Grandas Sagarra, Anna
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Other authors:
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Universitat de Barcelona |
Abstract:
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[2,5-Dimethylfuran]-protected maleimides were placed at both internal positions and the 3'-end of oligonucleotides making use of solid-phase synthesis procedures. A new phosphoramidite derivative and a new solid support incorporating the protected maleimide moiety were prepared for this purpose. In all cases maleimide deprotection (retro-Diels-Alder reaction) followed by reaction with thiol-containing compounds afforded the target conjugate. |
Subject(s):
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-Biotecnologia -Àcids nucleics -Espectrometria de masses -Nucleòtids -Compostos heterocíclics -Biotechnology -Nucleic acids -Mass spectrometry -Nucleotides -Heterocyclic compounds |
Rights:
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(c) Sánchez, Albert et al., 2012
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Document type:
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Article Article - Accepted version |
Published by:
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Royal Society of Chemistry
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