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dc.contributor | Universitat de Barcelona |
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dc.contributor.author | Garriga, César |
dc.contributor.author | García de Olalla, Patricia |
dc.contributor.author | Miró Meda, José M. |
dc.contributor.author | Ocaña, Inma |
dc.contributor.author | Knobel, Hernando |
dc.contributor.author | Barberá, Maria Jesús |
dc.contributor.author | Humet, Victoria |
dc.contributor.author | Domingo, Pere (Domingo Pedrol) |
dc.contributor.author | Gatell, José M. |
dc.contributor.author | Ribera, Esteban |
dc.contributor.author | Gurguí, Mercè |
dc.contributor.author | Marco, Andrés |
dc.contributor.author | Caylà i Buqueras, Joan A. |
dc.date | 2016-10-31T18:54:33Z |
dc.date | 2016-10-31T18:54:33Z |
dc.date | 2015-12-30 |
dc.date | 2016-10-31T18:54:38Z |
dc.identifier.citation | 1932-6203 |
dc.identifier.citation | 660894 |
dc.identifier.uri | http://hdl.handle.net/2445/103084 |
dc.description.abstract | Introduction Antiretroviral therapy has led to a decrease in HIV-related mortality and to the emergence of non-AIDS defining diseases as competing causes of death. This study estimates the HIV mortality rate and their risk factors with regard to different causes in a large city from January 2001 to June 2013. Materials and Methods We followed-up 3137 newly diagnosed HIV non-AIDS cases. Causes of death were classified as HIV-related, non-HIV-related and external. We examined the effect of risk factors on survival using mortality rates, Kaplan-Meier plots and Cox models. Finally, we estimated survival for each main cause of death groups through Fine and Gray models. Mortality Results 182 deaths were found [14.0/1000 person-years of follow-up (py); 95% confidence interval (CI):12.0-16.1/1000 py], 81.3% of them had a known cause of death. Mortality rate by HIV-related causes and non-HIV-related causes was the same (4.9/1000 py; CI:3.7-6.1/1000 py), external was lower [1.7/1000 py; (1.0-2.4/1000 py)]. Survival Results Kaplan-Meier estimate showed worse survival in intravenous drug user (IDU) and heterosexuals than in men having sex with men (MSM). Factors associated with HIV-related causes of death include: IDU male (subHazard Ratio (sHR):3.2; CI:1.5-7.0) and <200 CD4 at diagnosis (sHR:2.7; CI:1.3-5.7) versus ≥500 CD4. Factors associated with non-HIV-related causes of death include: ageing (sHR:1.5; CI:1.4-1.7) and heterosexual female (sHR:2.8; CI:1.1-7.3) versus MSM. Factors associated with external causes of death were IDU male (sHR:28.7; CI:6.7-123.2) and heterosexual male (sHR:11.8; CI:2.5-56.4) versus MSM. Conclusion and Recommendation There are important differences in survival among transmission groups. Improved treatment is especially necessary in IDUs and heterosexual males. |
dc.format | 19 p. |
dc.format | application/pdf |
dc.language.iso | eng |
dc.publisher | Public Library of Science (PLoS) |
dc.relation | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0145701 |
dc.relation | PLoS One, 2015, vol. 10, num. 12, p. e0145701 |
dc.relation | http://dx.doi.org/10.1371/journal.pone.0145701 |
dc.rights | cc-by (c) Garriga, César et al., 2015 |
dc.rights | info:eu-repo/semantics/openAccess |
dc.rights | http://creativecommons.org/licenses/by/3.0/es |
dc.subject | VIH (Virus) |
dc.subject | Mortalitat |
dc.subject | Epidemiologia |
dc.subject | Antiretrovirals |
dc.subject | HIV (Viruses) |
dc.subject | Mortality |
dc.subject | Epidemiology |
dc.subject | Antiretroviral agents |
dc.title | Mortality, Causes of Death and Associated Relate to a Large HIV Population-Based Cohort |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |