Stereoselectivesynthesis of (-)-lepadins A-C

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Title:	Stereoselectivesynthesis of (-)-lepadins A-C
Author:	Amat Tusón, Mercedes; Pinto, Alexandre; Griera Farres, Rosa; Bosch Cartes, Joan
Other authors:	Universitat de Barcelona
Abstract:	A concise synthesis of the marine alkaloids ()-lepadins A-C from a phenylglycinol-derived tricyclic lactam is reported. Key steps from the stereochemical standpoint involve stereoselective cyclocondensation, double bond hydrogenation, oxazolidine opening, hydroboration- oxidation, and Horner-Wadsworth-Emmons reactions.
Subject(s):	-Alcaloides -Lactames -Farmacologia -Alkaloids -Lactams -Pharmacology
Rights:	(c) Amat Tusón, Mercedes et al., 2013
Document type:	Article Article - Accepted version
Published by:	Royal Society of Chemistry
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