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Title: | Intercalative DNA binding of the marine anticancer drug variolin B |
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Author: | Canals, Albert; Arribas Bosacoma, Raquel; Albericio Palomera, Fernando; Alvarez Domingo, Mercedes; Aymami Bofarull, Juan; Coll, Miquel |
Other authors: | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química; Universitat Politècnica de Catalunya. MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques |
Abstract: | Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms. |
Abstract: | Peer Reviewed |
Subject(s): | -Àrees temàtiques de la UPC::Enginyeria química -Alkaloids -Crystals--Structure -DNA -Alcaloides -Cristalls -- Estructura -ADN |
Rights: | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Document type: | Article - Published version Article |
Published by: | Macmillan Publishers |
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