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Título:	Effect of Maraviroc intensification on HIV-1-specific T cell immunity in recently HIV-1-infected individuals
Autor/a:	Kawana-Tachikawa, Ai; Llibre, Josep M.; Bravo, Isabel; Escrig, Roser; Mothe, Beatriz; Puig, Jordi; Puertas, Maria C.; Martínez Picado, Francisco Javier; Blanco, Julià; Manzardo, Christian; Miró Meda, José M.; Iwamoto, Aikichi; Pozniak, Anton L.; Gatell, José M.; Clotet i Sala, Bonaventura; Brander, Christian
Otros autores:	Universitat de Barcelona
Abstract:	BACKGROUND: The effect of maraviroc on the maintenance and the function of HIV-1-specific T cell responses remains unknown. METHODS: Subjects recently infected with HIV-1 were randomized to receive anti-retroviral treatment with or without maraviroc intensification for 48 weeks, and were monitored up to week 60. PBMC and in vitro-expanded T cells were tested for responses to the entire HIV proteome by ELISpot analyses. Intracellular cytokine staining assays were conducted to monitor the (poly)-functionality of HIV-1-specific T cells. Analyses were performed at baseline and week 24 after treatment start, and at week 60 (3 months after maraviroc discontinuation). RESULTS: Maraviroc intensification was associated with a slower decay of virus-specific T cell responses over time compared to the non-intensified regimen in both direct ex-vivo as well as in in-vitro expanded cells. The effector function profiles of virus-specific CD8⁺ T cells were indistinguishable between the two arms and did not change over time between the groups. CONCLUSIONS: Maraviroc did not negatively impact any of the measured parameters, but was rather associated with a prolonged maintenance of HIV-1-specific T cell responses. Maraviroc, in addition to its original effect as viral entry inhibitor, may provide an additional benefit on the maintenance of virus-specific T cells which may be especially important for future viral eradication strategies.
Materia(s):	-Cèl·lules T -VIH (Virus) -Antiretrovirals -Resposta immunitària -Genètica molecular -T cells -HIV (Viruses) -Antiretroviral agents -Immune response -Molecular genetics
Derechos:	cc-by (c) Kawana-Tachikawa, Ai et al., 2014 http://creativecommons.org/licenses/by/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Public Library of Science (PLoS)
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