Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome

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dc.contributor	Universitat de Barcelona
dc.contributor.author	Rodriguez-Frias, Francisco
dc.contributor.author	Tabernero, David
dc.contributor.author	Quer, Josep
dc.contributor.author	Esteban, Juan I.
dc.contributor.author	Ortega, Israel
dc.contributor.author	Domingo, Esteban
dc.contributor.author	Cubero, Maria
dc.contributor.author	Camos, Sílvia
dc.contributor.author	Ferrer Costa, Carles
dc.contributor.author	Sànchez, Àlex (Sànchez Pla)
dc.contributor.author	Jardí, Rosendo
dc.contributor.author	Schaper, Melanie
dc.contributor.author	Homs, Maria
dc.contributor.author	García Cehic, Damir
dc.contributor.author	Guardia, Jaume
dc.contributor.author	Esteban, Rafael
dc.contributor.author	Buti, Maria
dc.date	2013-05-07T17:43:09Z
dc.date	2013-05-07T17:43:09Z
dc.date	2012-05-30
dc.date	2013-05-07T17:43:09Z
dc.identifier.citation	1932-6203
dc.identifier.citation	614276
dc.identifier.uri	http://hdl.handle.net/2445/43202
dc.format	15 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Public Library of Science (PLoS)
dc.relation	Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0037874
dc.relation	PLoS One, 2012, vol. 7, num. 5, p. e37874
dc.relation	http://dx.doi.org/10.1371/journal.pone.0037874
dc.rights	cc-by (c) Rodriguez Frías, F. et al., 2012
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.subject	Hepatitis B
dc.subject	Medicaments antivírics
dc.subject	Expressió gènica
dc.subject	Hepatitis B
dc.subject	Antiviral agents
dc.subject	Gene expression
dc.title	Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. In this study, the variability of an overlapping polymerase-surface region, critical for NA resistance, is investigated before treatment and under antiviral therapy, with assessment of NA-resistant amino acid changes simultaneously occurring in the same genome (linkage analysis) and their influence on the surface coding region.

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