Título:
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Triblock copolyesters derived from lactic acid and glucose: synthesis, nanoparticle formation and simulation
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Autor/a:
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Zakharova, Elena; León Cabanillas, Salvador; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián
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Otros autores:
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Química; Universitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics |
Abstract:
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ABA triblock copolyesters were synthesized by ring-opening polymerization (ROP) of l-lactide in solution initiated by a telechelic d-glucose-based polyester macroinitiator. The macroinitiator with a number-average molecular weight about 2500 g mol-1 was synthesized by non-stoichiometric polycondensation in the melt of 2,4:3,5-di-O-methylene-d-glucitol and dimethyl succinate. Two triblock copolyesters of Mn ranging between ~6000 and ~9000 g mol-1, and differing in the length of the polylactide blocks were prepared. These copolyesters started to decompose when heated at ~220 °C and degraded slowly upon aqueous incubation under physiological conditions. They did not display any perceivable crystallinity and showed a single glass transition temperature (Tg) around 60 °C with the higher value corresponding to the larger content in glucitol units. The copolyesters were able to form nanoparticles with average diameters of ~100–130 nm and satisfactory dispersity. The effect of the block lengths on size, ¿-potential values and physical stability of the nanoparticles was evaluated. A molecular dynamics simulation study allowed modelling the two-phase structure of the nanoparticles and evidenced the preference of the glucose-based block to be peripherally located. |
Abstract:
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Peer Reviewed |
Materia(s):
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-Àrees temàtiques de la UPC::Enginyeria química -Copolymers -Polymerization -Lactic block copolyester -Gludioxol block copolyester -Glucose derived -copolyester -Amphiphilic triblock copolyester -Bio-based triblock -copolyester -Block copolyester nanoparticles -Copolímers -Polimerització |
Derechos:
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Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Tipo de documento:
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Artículo - Versión presentada Artículo |
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