Título:
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Naturally acquired antibody responses to more than 300
Plasmodium vivax proteins in three geographic regions
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Autor/a:
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Longley, Rhea J.; White, Michael T.; Takashima, Eizo; Morita, Masayuki; Kanoi, Bernard N.; Li Wai Suen, Connie S. N.; Betuela, Inoni; Kuehn, Andrea; Sripoorote, Piyarat; Franca, Camila T.; Siba, Peter; Robinson, Leanne J.; Lacerda, Marcus Vinícius Guimarães; Sattabongkot, Jetsumon; Tsuboi, Takafumi; Mueller, Ivo
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Abstract:
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Plasmodium vivax remains an important cause of malaria in South
America and the Asia-Pacific. Naturally acquired antibody
responses against multiple P. vivax proteins have been described
in numerous countries, however, direct comparison of these
responses has been difficult with different methodologies
employed. We measured antibody responses against 307 P. vivax
proteins at the time of P. vivax infection, and at 2-3 later
time-points in three countries. We observed that seropositivity
rates at the time of infection were highest in Thailand,
followed by Brazil then PNG, reflecting the level of antigenic
input. The majority of sero-reactive antigens in all sites
induced short-lived antibody responses with estimated half-lives
of less than 6 months, although there was a trend towards
longer-lived responses in PNG children. Despite these
differences, IgG seropositivity rates, magnitude and longevity
were highly and significantly rank-correlated between the
different regions, suggesting such features are reflective of
the individual protein. |
Materia(s):
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-Plasmodium vivax -Malària -Plasmodium vivax -Malaria |
Derechos:
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cc by (c) Longley et al., 2017
http://creativecommons.org/licenses/by/4.0/ |
Tipo de documento:
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Artículo Artículo - Versión publicada |
Editor:
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Public Library of Science
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