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dc.contributor | Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa |
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dc.contributor | Universitat Politècnica de Catalunya. ADBD - Anàlisi de Dades Complexes per a les Decisions Empresarials |
dc.contributor | Universitat Politècnica de Catalunya. COSDA-UPC - COmpositional and Spatial Data Analysis |
dc.contributor.author | Puig Oriol, Xavier |
dc.contributor.author | Ginebra Molins, Josep |
dc.contributor.author | Graffelman, Jan |
dc.date | 2017-07 |
dc.identifier.citation | Puig, X., Ginebra, J., Graffelman, J. A bayesian test for Hardy-Weinberg equilibrium of bi-allelic X-chromosomal markers. "Heredity", Juliol 2017, núm. 119, p. 226-236. |
dc.identifier.citation | 0018-067X |
dc.identifier.citation | 10.1038/hdy.2017.30 |
dc.identifier.uri | http://hdl.handle.net/2117/110646 |
dc.description.abstract | The X chromosome is a relatively large chromosome, harboring a lot of genetic information. Much of the statistical analysis of X-chromosomal information is complicated by the fact that males only have one copy. Recently, frequentist statistical tests for Hardy–Weinberg equilibrium have been proposed specifically for dealing with markers on the X chromosome. Bayesian test procedures for Hardy–Weinberg equilibrium for the autosomes have been described, but Bayesian work on the X chromosome in this context is lacking. This paper gives the first Bayesian approach for testing Hardy–Weinberg equilibrium with biallelic markers at the X chromosome. Marginal and joint posterior distributions for the inbreeding coefficient in females and the male to female allele frequency ratio are computed, and used for statistical inference. The paper gives a detailed account of the proposed Bayesian test, and illustrates it with data from the 1000 Genomes project. In that implementation, a novel approach to tackle multiple testing from a Bayesian perspective through posterior predictive checks is used. |
dc.description.abstract | Peer Reviewed |
dc.language.iso | eng |
dc.relation | http://www.nature.com/hdy/journal/vaop/ncurrent/full/hdy201730a.html?foxtrotcallback=true |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights | info:eu-repo/semantics/openAccess |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica |
dc.subject | Bayesian statistical decision theory |
dc.subject | X chromosome |
dc.subject | Hardy-Weinberg equilibrium |
dc.subject | X-chromosome |
dc.subject | Inbreeding coeffcient |
dc.subject | Bayesian model selection |
dc.subject | Posterior distribution |
dc.subject | Dirichlet prior |
dc.subject | Estadística bayesiana |
dc.subject | Genètica -- Models estadístics |
dc.subject | Cromosomes |
dc.title | A bayesian test for Hardy-Weinberg equilibrium of bi-allelic X-chromosomal markers |
dc.type | info:eu-repo/semantics/submittedVersion |
dc.type | info:eu-repo/semantics/article |