To access the full text documents, please follow this link: http://hdl.handle.net/2445/118182

Title:	A role for caspase-8 and TRAIL-R2/DR5 in ER-stress induced apoptosis
Author:	Muñoz Pinedo, Cristina; López Rivas, Abelardo
Abstract:	Glab and colleagues examine in a recent paper apoptosis induced by some driverss of endoplasmic reticulum (ER) stress. They conclude that in contrast to a previously published report2 , DR5/TRAIL-R2 and caspase-8 are universally dispensable in ER stress-induced apoptosis. We argue here that their own data and other published reports indicate that in many models, DR5 and/or caspase-8 are essential players in apoptosis mediated by the unfolded protein response (UPR), upon chronic ER stress.
Subject(s):	-Proteïnes -Apoptosi -Proteins -Apoptosis
Rights:	(c) Cell Death & Differentiation, 2017
Document type:	Other Article - Accepted version
Published by:	Nature Publishing Group
Share:

Show full item record