dc.contributor |
Universitat de Barcelona |
dc.contributor.author |
Santos Vives, Alicia |
dc.contributor.author |
Resmini, Eugenia |
dc.contributor.author |
Gómez-Ansón, Beatriz |
dc.contributor.author |
Crespo, Iris |
dc.contributor.author |
Granell, Esther |
dc.contributor.author |
Valassi, Elena |
dc.contributor.author |
Pires, Patricia |
dc.contributor.author |
Vives-Gilabert, Yolanda |
dc.contributor.author |
Martínez Momblán, Ma. Antonia |
dc.contributor.author |
Juan, Manuel de |
dc.contributor.author |
Mataró Serrat, Maria |
dc.contributor.author |
Webb, S. M. (Susan M.), 1952- |
dc.date |
2018-01-18T12:02:22Z |
dc.date |
2018-01-18T12:02:22Z |
dc.date |
2015-12-01 |
dc.date |
2018-01-18T12:02:22Z |
dc.identifier.citation |
0804-4643 |
dc.identifier.citation |
655298 |
dc.identifier.uri |
http://hdl.handle.net/2445/119115 |
dc.format |
11 p. |
dc.format |
application/pdf |
dc.language.iso |
spa |
dc.publisher |
Bioscientifica |
dc.relation |
Versió postprint del document publicat a: http://www.eje-online.org/content/173/6/765.long |
dc.relation |
European Journal of Endocrinology, 2015, vol. 173, num. 6, p. 765-775 |
dc.rights |
(c) European Society of Endocrinology, 2015 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Síndrome de Cushing |
dc.subject |
Malalties cardiovasculars |
dc.subject |
Endocrinologia |
dc.subject |
Cushing's syndrome |
dc.subject |
Cardiovascular diseases |
dc.subject |
Endocrinology |
dc.title |
Cardiovascular risk and white matter lesions after endocrine control of Cushing's syndrome |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/acceptedVersion |
dc.description.abstract |
Objective: Cushing's syndrome (CS) is associated with high cardiovascular risk. White matter lesions (WML) are common on brain magnetic resonance imaging (MRI) in patients with increased cardiovascular risk. AIM: To investigate the relationship between cardiovascular risk, WML, neuropsychological performance and brain volume in CS. Design/methods: Thirty-eight patients with CS (23 in remission, 15 active) and 38 controls sex-, age- and education-level matched underwent a neuropsychological and clinical evaluation, blood and urine tests and 3Tesla brain MRI. WML were analysed with the Scheltens scale. Ten-year cardiovascular risk (10CVR) and vascular age (VA) were calculated according to an algorithm based on the Framingham heart study. Results: Patients in remission had a higher degree of WML than controls and active patients (P<0.001 and P=0.008 respectively), which did not correlate with cognitive performance in any group. WML severity positively correlated with diastolic blood pressure (r=0.659, P=0.001) and duration of hypertension (r=0.478, P=0.021) in patients in remission. Both patient groups (active and in remission) had higher 10CVR (P=0.030, P=0.041) and VA than controls (P=0.013, P=0.039). Neither the 10CVR nor the VA correlated with WML, although both negatively correlated with cognitive function and brain volume in patients in remission (P<0.05). Total brain volume and grey matter volume in both CS patient groups were reduced compared to controls (total volume: active P=0.006, in remission P=0.012; grey matter: active P=0.001, in remission P=0.003), with no differences in white matter volume between groups. Conclusions: Patients in remission of Cushing's syndrome (but not active patients) have more severe white matter lesions than controls, positively correlated with diastolic pressure and duration of hypertension. Ten-year cardiovascular risk and vascular age appear to be negatively correlated with the cognitive function and brain volume in patients in remission of Cushing's syndrome. |