Título:
|
Human primary osteoblast behaviour on microrough zirconia-toughened alumina and on selectively etched microrough zirconia-toughened alumina
|
Autor/a:
|
Stanciuc, Ana Maria; Flamant, Quentin; Biotteau Deheuvels, Katia; Stoddart, Martin J.; Anglada Gomila, Marcos Juan; Porporati, Alessandro A.; Kuntz, Meinhard; Gremillard, Laurent; Alini, Mauro; Peroglio, Marianna
|
Otros autores:
|
Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Universitat Politècnica de Catalunya. CIEFMA - Centre d'Integritat Estructural, Micromecànica i Fiabilitat dels Materials |
Abstract:
|
Hip arthroplasty cementless acetabular components require excellent mechanical properties, biocompatibility, low friction and good osseointegration with surrounding bone tissue. Zirconia-toughened alumina (ZTA) fulfils these demands but requires combination with a rough metal shell for adequate osseointegration. Surface modifications of ZTA could allow a metal-free solution, thus preserving the bone stock for an eventual revision surgery. In this study, selective chemical etching proved to be an innovative method for the introduction of nano-features on micro-rough surfaces obtained by injection moulding. Results suggest that micro-roughness, fluorine enrichment and nano-porosity at the surface of ZTA play a synergistic role on human osteoblast (hOb) maturation. Among the tested groups, hydrofluoric acid etched “medium” roughness (Sa = 330 nm) ZTA showed the highest and/or earliest ALP expression at both the protein and gene level, while microroughness alone induced only minor effects on hOb maturation on ZTA. |
Abstract:
|
Peer Reviewed |
Materia(s):
|
-Àrees temàtiques de la UPC::Enginyeria dels materials -Osseointegration -Osseointegration -Micro-roughness -Nano-roughness -Human primary osteoblast -Selective chemical etching -Osseointegració |
Derechos:
|
|
Tipo de documento:
|
Artículo - Versión publicada Artículo |
Editor:
|
Elsevier
|
Compartir:
|
|