Bioanalytical techniques in discrimination between therapeutic and abusive use of drugs in sport

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dc.contributor.author	Ventura Alemany, Rosa
dc.contributor.author	Matabosch Geronès, Xavier
dc.contributor.author	Segura, Joan
dc.date	2016
dc.identifier.citation	Ventura R, Matabosch X, Segura J. Bioanalytical techniques in discrimination between therapeutic and abusive use of drugs in sport. Bioanalysis. 2016 May;8(9):965-80. doi: 10.4155/bio.15.253
dc.identifier.citation	1757-6180
dc.identifier.citation	http://dx.doi.org/10.4155/bio.15.253
dc.identifier.uri	http://hdl.handle.net/10230/26790
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Future Science
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.rights	This is the author's final version of the following article: Ventura R, Matabosch X, Segura J. Bioanalytical techniques in discrimination between therapeutic and abusive use of drugs in sport. Bioanalysis. 2016 May;8(9):965-80, which has been published in final form at http://dx.doi.org/10.4155/bio.15.253.
dc.subject	Dopatge en els esports
dc.subject	Glucocorticoides
dc.title	Bioanalytical techniques in discrimination between therapeutic and abusive use of drugs in sport
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion
dc.description.abstract	The discrimination between therapeutic and abusive use of drugs in sports is performed using threshold concentrations or reporting levels, and the detection of the substances in a sample is only reported as an adverse analytical finding when the concentration exceeds the threshold or the reporting level. In this paper, the strategies of discrimination and the analytical methods used for the main groups of substances where the distinction is needed (β-2 agonists, ephedrines, glucocorticoids and morphine) will be reviewed. Nowadays, LC-MS is the method of choice for the analysis of these substances and, in most of the cases, a simple dilution of the urine sample is performed before the chromatographic analysis.
dc.description.abstract	The financial support received from Consell Català de l’Esport and DIUE (2014 651 SGR 692) (Generalitat de Catalunya, Spain) and the World Antidoping Agency 652 (grants 13D22RV and 14D06RV) is acknowledged

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