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Title:	Translation control: Learning from viruses, again
Author:	Díez Antón, Juana, 1962-; Jungfleisch, Jennifer, 1986-
Abstract:	Viruses are powerful tools to uncover cellular processes. Through viral studies we have recently identified a novel translational control mechanism that involves the DEAD-box helicase Dhh1/DDX6 and RNA folding within coding sequences (CDSs). All Dhh1-dependent mRNAs, viral and cellular ones, (i) contain long and highly structured CDSs, (ii) are directly bound by Dhh1 with a specific pattern, (iii) are activated at the translation initiation step and (iv) express proteins associated with the endoplasmic reticulum. The obtained results uncover a novel layer of translation regulation associated with translation at the endoplasmic reticulum conserved from yeast to humans and hijacked by viruses.
Abstract:	This work was supported by the Spanish Ministry of Economy and Competitiveness through grant BFU2016–80039-R (AEI/MINEICO/FEDER, UE) and the “Maria de Maeztu” Program for Units of Excellence in R&D (MDM-2014–0370).
Subject(s):	-BMV -Dhh1 -Helicase -RNA secondary structure -Translational regulation -Viral RNA
Rights:	info:eu-repo/semantics/embargoedAccess © Taylor & Francis. This is an electronic version of an article published in Díez Antón J, Jungfleisch J. Translation control: Learning from viruses, again. RNA Biology. 2017 [Epub ahead of print]. RNA Biology is available online at: www.tandfonline.com http://dx.doi.org/10.1080/15476286.2017.1325068.
Document type:	Article Article - Accepted version
Published by:	Taylor & Francis (Routledge)
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