Título:
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Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids
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Autor/a:
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Puighermanal Puigvert, Emma, 1983-; Busquets Garcia, Arnau, 1985-; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969-
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Abstract:
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Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds modulate a number of signalling pathways critically implicated in the deleterious effect of cannabinoids on learning and memory. Thus, the involvement of the mammalian target of rapamycin pathway and extracellular signal-regulated kinases, together with their consequent regulation of cellular processes such as protein translation, play a critical role in the amnesic-like effects of cannabinoids. In this study, we summarize the cellular and molecular mechanisms reported in the modulation of cognitive function by the endocannabinoid system. |
Abstract:
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EP is a recipient of an EMBO Fellowship with the support of European Commission (EMBOCOFUND2010, GA-2010-267146) and Marie Curie Actions. AB-G is a recipient of a predoctoral fellowship, Spanish Ministry of Education and Culture. This study was supported by grants from La Marató de TV3 (#090910 to AO), Grants from the Spanish Ministry of Science and Innovation (#SAF2009-07309 to AO and/n#SAF2011-29864 to RM); Instituto de Salud Carlos III (RD06/0001/0001 to RM); PLAN E (Plan Español para el Estímulo de la Economía y el Empleo); Generalitat de Catalunya (SGR-2009-00731 to RM and SGR-2009-00718 to RdlT); ICREA (Institució Catalana de Recerca i Estudis Avançats) Academia to RM |
Materia(s):
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-Trastorns de la cognició -Cannabinoides |
Derechos:
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© The Royal Society. http://dx.doi.org/10.1098/rstb.2011.0384 |
Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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Royal Society
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Compartir:
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