Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1

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dc.contributor.author	Herrmann, Madeleine
dc.contributor.author	Ruprecht, Klemens
dc.contributor.author	Sauter, Marlies
dc.contributor.author	Martinez, Javier P.
dc.contributor.author	van Heteren, Pearl
dc.contributor.author	Glas, Michael
dc.contributor.author	Best, Barbara
dc.contributor.author	Meyerhans, Andreas
dc.contributor.author	Roemer, Klaus
dc.contributor.author	Mueller-Lantzsch, Nikolaus
dc.date	2010
dc.identifier.citation	Herrmann M, Ruprecht K, Sauter M, Martinez J, van Heteren P, Glas M et al. Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1. FEBS Letters. 2010; 584(16): 3513-3518. DOI 10.1016/j.febslet.2010.07.016DOI 10.1007/s00249-010-0612
dc.identifier.citation	0014-5793
dc.identifier.citation	http://dx.doi.org/10.1016/j.febslet.2010.07.016
dc.identifier.uri	http://hdl.handle.net/10230/25585
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation	FEBS Letters. 2010; 584(16): 3513-3518
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	© Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.febslet.2010.07.016 that appeared in the journal FEBS Letters. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-license
dc.subject	VIH (Virus)
dc.subject	RNA missatger
dc.subject	Human immunodeficiency virus
dc.subject	Immunodeficiency virus
dc.subject	Glycoprotein 120
dc.title	Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Retrovirus replication critically depends on a dynamic interplay between retroviral and host proteins. We report on the binding of the surface subunit (glycoprotein 120 (gp120)) of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) to the cytoplasmic C-terminus of the voltage-gated potassium channel BEC1 (brain-specific ether-a-go-go-like channel 1), an interaction that can result in the repression of BEC's activity and the inhibition of HIV-1 particle-release. BEC1 protein was found to be expressed in T cells and macrophages, the major target cells of HIV-1. Thus, gp120/BEC1 interaction may be involved in HIV-1 life cycle and/or pathogenesis.
dc.description.abstract	This study was supported by grants from the Deutsche Forschungsgemeinschaft (DFG) and Deutscher Akademischer Austauschdienst (DAAD).

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