Título:
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Multiplicative and additive modulation of neuronal tuning with population activity affects encoded information
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Autor/a:
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Arandía Romero, Iñigo; Tanabe, Seiji; Drugowitsch, Jan; Kohn, Adam; Moreno Bote, Rubén
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Abstract:
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Numerous studies have shown that neuronal re-
sponses are modulated by stimulus properties and
also by the state of the local network. However, little
is known about how activity fluctuations of neuronal
populations modulate the sensory tuning of cells and
affect their encoded information. We found that fluc-
tuations in ongoing and stimulus-evoked population
activity in primate visual cortex modulate the tuning
of neurons in a multiplicative and additive manner.
While distributed on a continuum, neurons with
stronger multiplicative effects tended to have less
additive modulation and vice versa. The information
encoded by multiplicatively modulated neurons
increased with greater population activity, while
that of additively modulated neurons decreased.
These effects offset each other so that population ac-
tivity had little effect on total information. Our results
thus suggest that intrinsic activity fluctuations may
act as a ‘‘traffic light’’ that determines which subset
of neurons is most informative. |
Abstract:
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I.A.-R. is supported by a PhD grant from the Department of Education, Linguistic Politics, and Culture of the Basque Government. A.K. is supported by the NIH (EY016774), an Irma T. Hirschl Career Scientist Award, and Research to Prevent Blindness. R.M.-B. is supported by the Ramon y Cajal Spanish Award RYC-2010-05952, the Marie Curie FP7-PEOPLE-2010-IRG grant PIRG08-GA-2010-276795, and the Spanish PSI2013-44811-P grant. I.A.-R. |
Materia(s):
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-visual cortex -neural populations -global fluctuations -population activity -decoding -tuning curve -slow oscillations -slow oscillations |
Derechos:
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© Elsevier http://dx.doi.org/10.1016/j.neuron.2016.01.044 |
Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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Elsevier
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Compartir:
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