dc.contributor.author |
Cristelli, M.P. |
dc.contributor.author |
Cofán, F. |
dc.contributor.author |
Rico, N. |
dc.contributor.author |
Trullàs Vila, Juan Carlos |
dc.contributor.author |
Manzardo, C. |
dc.contributor.author |
Agüero, Fernando |
dc.contributor.author |
Bedini, J.L. |
dc.contributor.author |
Moreno, A. |
dc.contributor.author |
Oppenheimer, F. |
dc.contributor.author |
Miró, J.M. |
dc.date |
2017-06-15T09:58:27Z |
dc.date |
2017-06-15T09:58:27Z |
dc.date |
2017-02-10 |
dc.identifier.citation |
1471-2369 |
dc.identifier.citation |
026766 |
dc.identifier.uri |
http://hdl.handle.net/10256/14205 |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
BioMed Central |
dc.relation |
http://dx.doi.org/10.1186/s12882-017-0470-4 |
dc.relation |
Reproducció digital del document publicat a: http://dx.doi.org/10.1186/s12882-017-0470-4 |
dc.relation |
BMC Nephrology, 2017, vol. 18, p. 58 |
dc.relation |
Articles publicats (D-CM) |
dc.rights |
Attribution 3.0 Spain |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
http://creativecommons.org/licenses/by/3.0/es/ |
dc.subject |
Persones seropositives |
dc.subject |
HIV-positive persons |
dc.subject |
Ronyons -- Malalties |
dc.subject |
Kidneys -- Diseases |
dc.title |
Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has greater diagnostic accuracy. To date, however, little information exists on patients with HIV-infection. This study aimed to evaluate eGFR by CKD-EPI vs. MDRD equations and to stratify renal function according to KDIGO guidelines.
Methods: Cross-sectional, single center study including adult patients with HIV-infection.
Results: Four thousand five hundred three patients with HIV-infection (864 women; 19%) were examined. Median age was 45 years (IQR 37–52), and median baseline creatinine was 0.93 mg/dL (IQR 0.82–1.05). A similar distribution of absolute measures of eGFR was found using both formulas (p = 0.548). Baseline median eGFR was 95.2 and 90.4 mL/min/1.73 m2 for CKD-EPI and MDRD equations (p < 0.001), respectively. Of the 4503 measurements, 4109 (91.2%) agreed, with a kappa index of 0.803. MDRD classified 7.3% of patients as “mild reduced GFR” who were classified as “normal function” with CKD-EPI. Using CKD-EPI, it was possible to identify “normal function” (>90 mL/min/1.73 m2) in 73% patients and “mild reduced GFR” (60–89 mL/min/1.73 m2) in 24.3% of the patients, formerly classified as >60 mL/min/1.73 m2 with MDRD.
Conclusions: There was good correlation between CKD-EPI and MDRD. Estimating renal function using CKD-EPI equation allowed better staging of renal function and should be considered the method of choice. CKD-EPI identified a significant proportion of patients (24%) with mild reduced GFR (60–89 mL/min/1.73 m2) |