Title:
|
Development of a computational model of abscess formation
|
Author:
|
Pigozzo, Alexandre B.; Missiakas, Dominique; Alonso Muñoz, Sergio; Weber dos Santos, Rodrigo; Lobosco, Marcelo
|
Other authors:
|
Universitat Politècnica de Catalunya. Departament de Física; Universitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos |
Abstract:
|
In some bacterial infections, the immune system cannot eliminate the invading pathogen. In these cases, the invading pathogen is successful in establishing a favorable environment to survive and persist in the host organism. For example, S. aureus bacteria survive in organ tissues employing a set of mechanisms that work in a coordinated and highly regulated way allowing: (1) efficient impairment of the immune response; and (2) protection from the immune cells and molecules. S. aureus secretes several proteins including coagulases and toxins that drive abscess formation and persistence. Unless staphylococcal abscesses are surgically drained and treated with antibiotics, disseminated infection and septicemia produce a lethal outcome. Within this context, this paper develops a simple mathematical model of abscess formation incorporating characteristics that we judge important for an abscess to be formed. Our aim is to build a mathematical model that reproduces some characteristics and behaviors that are observed in the process of abscess formation. |
Abstract:
|
Peer Reviewed |
Subject(s):
|
-Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica -Computational biology -S. aureus infection -abscess formation -fibrin network -partial differential equation -computational modeling -Biologia computacional |
Rights:
|
Attribution 3.0 Spain
http://creativecommons.org/licenses/by/3.0/es/ |
Document type:
|
Article - Published version Article |
Share:
|
|