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Título:	Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes
Autor/a:	Gamarra Montes, Ana; Missagia, Beatriz; Urpí Garriga, Lourdes; Morató Farreras, Jordi; Muñoz Guerra, Sebastián
Otros autores:	Universitat Politècnica de Catalunya. Departament d'Enginyeria Química; Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria; Universitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics; Universitat Politècnica de Catalunya. SUMMLab - Sustainability Measurement and Modeling Lab
Abstract:	Ethyl alpha-N-lauroyl L-arginate hydrochloride (LAE) was coupled with hyaluronic acid (HyA) 2 to form ionic complexes with LAE to HyA ratios of 1:1 and 1:2. The complexes were extensively 3 characterized by FTIR and NMR spectroscopies and their thermal properties evaluated by 4 thermogravimetry and calorimetry. Thin films prepared from these complexes by casting 5 displayed a smectic-like structure based on an ordered arrangement of LAE and HyA layers 6 with a nanometric periodicity of 3.8-3.9 nm. Films immersed in water at pH 7.4 and 5.5 7 dissociated to deliver free LAE to the environment and reaching the equilibrium in few hours. 8 The biocide activity of these films against both Gram-positive and Gram-negative bacteria was 9 preliminary assessed by the liquid medium method, and shown to be notable in both cases. The 10 antibacterial property of the complexes was found to increase with the content of LAE and to be 11 particularly efficient against Gram-negative S. enterica bacteria.
Abstract:	Peer Reviewed
Materia(s):	-Àrees temàtiques de la UPC::Enginyeria química -Antimicrobial polymers -Ethyl alpha-N-lauroyl L-arginate -LAE -hyaluronic acid -ionic complexes -biocide activity -Biopolímers
Derechos:	Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Tipo de documento:	Artículo - Versión presentada Artículo
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