Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity

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RECERCAT Home > Universitat de Barcelona > Institut de Biomedicina (IBUB) > Articles publicats en revistes (Institut de Biomedicina (IBUB)) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/61086

dc.contributor	Universitat de Barcelona
dc.contributor.author	Amat Tusón, Mercedes
dc.contributor.author	Köver, Andrea
dc.contributor.author	Jokic, Danica
dc.contributor.author	Lozano, Oscar
dc.contributor.author	Pérez Bosch, Maria
dc.contributor.author	Landoni, Nicola
dc.contributor.author	Subrizi, Fabiana
dc.contributor.author	Bautista, Jesús
dc.contributor.author	Bosch Cartes, Joan
dc.date	2015-01-08T18:30:18Z
dc.date	2015-01-08T18:30:18Z
dc.date	2010
dc.date	2015-01-08T18:30:19Z
dc.identifier.citation	1551-7012
dc.identifier.citation	568739
dc.identifier.uri	http://hdl.handle.net/2445/61086
dc.format	7 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Michigan Publishing
dc.relation	Reproducció del document publicat a: http://dx.doi.org/10.3998/ark.5550190.0011.313
dc.relation	Arkivoc, vol. 2010, núm. 3, p. 145-151
dc.relation	http://dx.doi.org/10.3998/ark.5550190.0011.313
dc.rights	cc-by-nc (c) Amat Tusón, Mercedes et al., 2010
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc/3.0/es
dc.subject	Bioquímica
dc.subject	Amines
dc.subject	Dianes farmacològiques
dc.subject	Proteïnes quinases
dc.subject	Transducció de senyal cel·lular
dc.subject	Biochemistry
dc.subject	Amines
dc.subject	Drug targeting
dc.subject	Protein kinases
dc.subject	Cellular signal transduction
dc.title	Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	A straightforward synthesis of the Met antagonist JLK1360 involving an alkylationcyclocondensation process using aminothiazole 1 and nitrophenacyl bromide 2, reduction of the nitro group, and coupling of the resulting tetracyclic aniline 5 with an appropriate N-acyl alanine derivative, is reported.

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